Translational Research in Cardiovascular Repair: A Call for a Paradigm Shift

Translational Research in Cardiovascular Repair: A Call for a Paradigm Shift

Steven A.J. Chamuleau, Mira van der Naald, Andreu M. Climent, Adriaan O. Kraaijeveld, Kim E. Wever, Dirk J. Duncker, Francisco Fernández-Avilés, Roberto Bolli
and on behalf of the Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes (TACTICS) Group

Translational axis, with stage I studies (including in vitro studies and zebrafish models) to investigate basic mechanisms and discover new proteins and pathways; stage II studies (exploratory studies), predominantly in mouse models, to conduct hypothesis-generating research and initial in vivo testing; and stage III studies (confirmatory studies), as the last step before entering the clinical arena, involving rigorous research in a multicentre setting, with prospective registration of the key features of the study. Preclinical meta-analyses are performed with data from both exploratory and confirmatory studies, with the goal of giving an overview of available data, pointing out the gaps, and providing a guideline for future preclinical research. The level of standardization of methodology increases through the translational axis. [Powerpoint File]

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