Translational Challenges in Atrial Fibrillation

Translational Challenges in Atrial Fibrillation

Jordi Heijman, Jean-Baptiste Guichard, Dobromir Dobrev, Stanley Nattel

Photoacoustic imaging to define patient-specific atrial fibrillation mechanisms. Photoacoustic imaging uses (1) a pulsed-wave laser beam to activate endogenous (eg, water molecules, lipids, collagen) or exogenous photoabsorbing molecules, producing (2) thermal vibrations that generate (3) acoustic waves, which can be detected and localized using (4) ultrasound. Integration of photoacoustic imaging in an electrophysiology catheter in combination with intracardiac echocardiography could be used to assess ablation lesions (through endogenous chromophores) and perform in vivo Ca2+ imaging through novel cell-permeable photoacoustic Ca2+ indicators. [Powerpoint File]

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