The Expanding Complexity of Estrogen Receptor Signaling in the Cardiovascular System

The Expanding Complexity of Estrogen Receptor Signaling in the Cardiovascular System

Sara Menazza, Elizabeth Murphy

Orphan G-protein–coupled receptor (GRP30) activation via endothelium-independent or endothelium-dependent mechanisms. A, Endothelium-independent effect is mediated by a large conductance calcium-activated potassium channel leading to an increase in potassium efflux. This effect results in coronary artery relaxation. BK indicates Ca2+- and voltage-activated K+ channels. B, Endothelium-dependent mechanism. Estrogen binding to GPR30 leads to activation of endothelial nitric oxide (NO) synthase raising the production of NO in coronary endothelial cells to relax these arteries. [Powerpoint File]

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