Posts Tagged: ischemic stroke

Vascular Cognitive Impairment

Vascular Cognitive Impairment

Martin Dichgans, Didier Leys

Major mechanisms underlying vascular cognitive impairment (VCI). A, Vascular causes. B, Brain parenchymal lesions associated with VCI. For explanations, see text. WML indicates white matter lesion (graphical realization: Antonia Weingart, Institute for Stroke and Dementia Research). [Powerpoint File]

Vascular Cognitive Impairment

Vascular Cognitive Impairment

Martin Dichgans, Didier Leys

Pathological findings associated with vascular cognitive impairment (VCI). A, Hemisphere section of a patient with small-vessel disease and extensive white matter rarefication (Luxol fast blue periodic acid Schiff-reaction [LFB-PAS] stain, scale bar 1 cm); the arrowhead marks a lacunar infarct; boxes correspond to higher magnifications in B, C, and D. B, Enlarged perivascular space (LFB-PAS stain, scale bar 200 μm). C, Mild white matter rarefication (pallor; LFB-PAS stain, scale bar 500 μm). D, Marked white matter rarefication (pallor; LFB-PAS stain, scale bar 500 μm). E, Lacunar infarct (hematoxilin and eosin stain, scale bar 500 μm). F, Microhemorrhage with hemosiderin-loaded macrophages (hematoxilin and eosin stain, scale bar 200 μm). G, Microinfarct (hematoxilin and eosin stain, scale bar 200 μm). Images were kindly provided by Thomas Arzberger and Karl Bise, Institute for Neuropathology and Prion Research, LMU, Munich. [Powerpoint File]