Posts Tagged: differentiation

MicroRNAs and Stem Cells: Control of Pluripotency, Reprogramming, and Lineage Commitment

MicroRNAs and Stem Cells: Control of Pluripotency, Reprogramming, and Lineage Commitment

Eva-Marie Heinrich, Stefanie Dimmeler

MicroRNAs (miRs) in cardiovascular lineage commitment. Some miRs have been shown to directly control lineage commitment, whereas the majority of miRs control the functional maturation of the differentiated cells. Arrows indicate regulation during differentiation. [Powerpoint File]

Vascular Smooth Muscle Progenitor Cells: Building and Repairing Blood Vessels

Vascular Smooth Muscle Progenitor Cells: Building and Repairing Blood Vessels

Mark W. Majesky, Xiu Rong Dong, Jenna N. Regan, Virginia J. Hoglund

Sources of vascular smooth muscle progenitor cells in adults. In large arteries (red) and veins (gray), resident SMC progenitors have been identified in the adventitial layer (green cell clusters) and in the medial layer (scattered blue cells). Some reports suggest that SMCs in atherosclerotic plaques and intimal masses can arise from circulating, bone marrow–derived progenitor cells (yellow), whereas others report finding no evidence to support that possible origin. In microvessels, pericytes (purple) have multilineage differentiation potentials and can act as SMC progenitor cells. [Powerpoint File]