Posts Tagged: computational biology

Long Noncoding RNA Discovery in Cardiovascular Disease: Decoding Form to Function

Long Noncoding RNA Discovery in Cardiovascular Disease: Decoding Form to Function

Tamer Sallam, Jaspreet Sandhu, Peter Tontonoz

Pipeline of long noncoding RNA (lncRNA) discovery and characterization. ASO indicates antisense oligonucleotide; ChiRP, chromatin isolation by RNA purification; qPCR, quantitative polymerase chain reaction; RAP, RNA antisense purification; and RIP, RNA immunoprecipitation. [Powerpoint File]

“Good Enough Solutions” and the Genetics of Complex Diseases

“Good Enough Solutions” and the Genetics of Complex Diseases

James N. Weiss, Alain Karma, W. Robb MacLellan, Mario Deng, Christoph D. Rau, Colin M. Rees, Jessica Wang, Nicholas Wisniewski, Eleazar Eskin, Steve Horvath, Zhilin Qu, Yibin Wang, Aldons J. Lusis

“Good enough solutions” in the somato-gastric ganglia of lobsters. A, Schema of the somato-gastric ganglion (above), whose bursting pattern controls digestive activity in the lobster (below). B, All lobsters exhibit very similar bursting activities (green and orange traces). C, However, different lobsters use different combinations of ionic conductances (left) and corresponding ion channel gene expression levels (right) to produce the nearly identical bursting patterns. Adapted from Marder,5 with permission. [Powerpoint File]