Posts Tagged: chymases

Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling

Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling

Louis J. Dell’Italia, James F. Collawn, Carlos M. Ferrario

Evidence from human pathology and preclinical animal models supports the important role for chymase in cardiovascular stress. Upper left, Demonstrates a cross-section of a human renal artery with marked increase in chymase (brown) extending from the endothelium to adventitia in a patient with diabetes mellitus (reprinted from Koka et al60 with permission. Copyright ©2006, Wolters Kluwer Health). Center and upper right, Cartoons demonstrate the potential role of chymase in attenuating ischemia/reperfusion injury and promoting stabilization of the vulnerable atherosclerotic plaque (reprinted from Bentzon et al249 with permission. Copyright ©2014, Wolters Kluwer Health). Bottom right, Demonstrate the marked increase in left ventricular (LV) volume and LV wall thinning in a patient with chronic mitral regurgitation (MR; right) compared with a normal subject (left; reprinted from Zheng et al250 with permission. Copyright ©2014, Wolters Kluwer Health). Bottom left, Demonstrates the increase in LV volume and apical wall thinning in a patient 6 mo after an antero-apical myocardial infarction (MI; right) compared with 3 d after MI (left; reprinted from Foster et al251 with permission. Copyright ©1998, Elsevier). Targeting the multifunctional roles of chymase (Figure 2) in each of these conditions by chymase inhibition will complement conventional renin–angiotensin system (RAS) blockade in promoting better outcomes and tissue protection. [Powerpoint File]