Posts Tagged: cell plasticity

Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration

Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration

Hui Zhang, Kathy O. Lui, Bin Zhou

Mural cells derived from endocardium in developing heart. A and B, Endocardial cells undergo endothelial to mesenchymal transition to form PDGFRβ+PDGFRα+NG2– mesenchymal cells in the cardiac cushion (black arrows). C and D, Mesenchymal cells migrate into myocardium (white arrows) to form PDGFRβ+PDGFRα–NG2+αSMA+ smooth muscle cells or PDGFRβ+PDGFRα–NG2+αSMA– pericytes. [Powerpoint File]

Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration

Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration

Hui Zhang, Kathy O. Lui, Bin Zhou

Molecular regulation of endocardial cushion endothelial to mesenchymal transition (EndoMT). Multiple signaling pathways including BMP (bone morphogenetic protein), TGFβ (transforming growth factor-β), and Notch control endocardial contribution to cushion morphogenesis through regulating EndoMT. AVC indicates atrioventricular canal; Msx, msh homeobox; OFT, outflow tract; Rbpj, recombination signal binding protein for immunoglobulin kappa J region; Slug, snail family zinc finger 2; Snail, snail family zinc finger 1; and Twist, twist basic helix–loop–helix transcription factor. [Powerpoint File]

Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration

Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration

Hui Zhang, Kathy O. Lui, Bin Zhou

Schematic showing the endocardial cell plasticity. Endocardial cell (in the center) differentiates into hematopoietic cell, cushion mesenchyme, coronary, liver vascular endothelial cell, and cardiomyocyte (arrows). Question (?) indicates that the cardiomyocyte fate needs validated. Endocardial cell also contributes to fibroblast, adipocyte, pericyte, and smooth muscle cell (dotted arrows), which might be through intermediate stage of mesenchymal cell. [Powerpoint File]