Mending a Faltering Heart

Mending a Faltering Heart

Mo Li, Juan Carlos Izpisua Belmonte

Recent strategies for cardiomyocyte regeneration. Cardiomyocytes can be induced to re-enter the cell cycle through modulation of endogenous cardiomyocyte proliferation programs. Reprogramming to induced pluripotent stem cell (iPSCs) followed by directed differentiation could provide a large number of immature cardiomyocytes. Other noncardiomyocyte cells, such as fibroblasts, can be directly converted to induced cardiomyocytes (iCMs). These in vitro derived cardiomyocytes may be further matured using tissue engineering technologies. In situ conversion of cardiac fibroblasts also represents a promising strategy for heart repair. MI indicates myocardial infarction. [Powerpoint File]

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