Engineering Cardiac Muscle Tissue: A Maturating Field of Research

Engineering Cardiac Muscle Tissue: A Maturating Field of Research

Florian Weinberger, Ingra Mannhardt, Thomas Eschenhagen

Histological structure of native mouse and rat heart (longitudinal mouse heart in A; cross section of rat heart in B), engineered heart tissue (EHT) from neonatal rat heart cells (longitudinal in C, E, cross section in D), or human pluripotent stem cell–derived cardiomyocytes (F–J). A, staining of actinin (green). B, Staining of sarcolemma with wheat germ agglutinin (white in B). C and D, Staining of actinin (red in C and I), F-actin (green in D and J), or actinin and troponin T (green/red in H) and nuclei in blue (all). E, Hematoxylin and eosin–stained paraffin section. A, Reprinted from Mearini et al135 with permission of the publisher. Copyright © 2014, Macmillan Publishers Limited. B, Reprinted from Bensley et al136 with permission. Copyright © 2016, The Authors. C, D, I, and J, Reprinted from Jackman et al35 with permission of the publisher. Copyright © 2016, Elsevier; and from Eschenhagen et al134 (E) with permission of the publisher. Copyright © 2012, the American Physiological Society. F, Reprinted from Hirt et al36 with permission of the publisher. Copyright © 2014, Elsevier. G, Reprinted from Mannhardt et al78 with permission. Copyright © 2016, The Authors. H, Riegler et al93 with permission of the publisher. Copyright © 2015, American Heart Association. [Powerpoint File]

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