Elixir of Life: Thwarting Aging With Regenerative Reprogramming

Elixir of Life: Thwarting Aging With Regenerative Reprogramming

Ergin Beyret, Paloma Martinez Redondo, Aida Platero Luengo, Juan Carlos Izpisua Belmonte

Regenerative reprogramming approaches. In vivo induction of transdifferentiation can be used to repopulate the cells lost during aging as an alternative to transplantation, complementing the intrinsic regenerative capacity. For instance, neurons lost to neurodegenerative diseases can be replaced by transdifferentiating resident glia or astrocytes; cardiac fibroblasts can be the cell source for induced cardiomyocytes; α, ductal, and acinar cells can be used for β cells. Alternatively, transient 4F (OCT4, KLF4, SOX2, and c-Myc) expression can be used to rejuvenate cells. This in turn can decelerate degeneration of biological units that have low regeneration capacity (eg, aorta) or augment regeneration capacity by counteracting stem cell exhaustion (eg, muscle) or by enhancing the plasticity of organs that intrinsically undergo cell conversions during regeneration (eg, transdifferentiation in the pancreas and dedifferentiation in the kidney). MuSC indicates muscle stem cell. [Powerpoint File]

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