Current Status and Future Potential of Transcatheter Interventions in Congenital Heart Disease

Current Status and Future Potential of Transcatheter Interventions in Congenital Heart Disease

Damien P. Kenny, Ziyad M. Hijazi

Cartoon illustrating possible future strategies for the surgical management of newborns with congenital heart disease (CHD). If CHD is diagnosed prenatally, fetal cells may be harvested and induced pluripotent stem cells (iPS) generated; as an alternative, umbilical cord stem cells can be isolated at the time of birth. When diagnosis of CHD is made after birth or in babies who require a palliative surgical operation soon after birth, stem cells may be isolated from surgical cardiac leftovers. All these types of cells will allow the generation of a tissue-engineered graft endowed with growth and remodeling potential, necessary for the definitive correction of cardiac defects (Taken from Avolio et al99; Illustration Credit: Ben Smith). [Powerpoint File]

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