Posts in Category: Imaging & Diagnostic Testing

Myocardial Viability: Survival Mechanisms and Molecular Imaging Targets in Acute and Chronic Ischemia

Myocardial Viability: Survival Mechanisms and Molecular Imaging Targets in Acute and Chronic Ischemia

Henry Gewirtz, Vasken Dilsizian

Diagrammatic representation of myocardial cell and potential targets of radiotracer imaging and mapping of the surface renin–angiotensin system. ACE indicates angiotensin-converting enzyme; AGT, angiotensinogen; Ang II, angiotensin II; AT1R, angiotensin II type 1 receptor; and AT2R, angiotensin II type 2 receptor. Reproduced with permission from Schindler and Dilsizian.61 Copyright © 2012, Elsevier. [Powerpoint File]

Myocardial Viability: Survival Mechanisms and Molecular Imaging Targets in Acute and Chronic Ischemia

Myocardial Viability: Survival Mechanisms and Molecular Imaging Targets in Acute and Chronic Ischemia

Henry Gewirtz, Vasken Dilsizian

Myocyte metabolic pathways outlined for glucose and fatty acid metabolism with focus on the mitochondrion. The electron transport chain (ETC), complexes I–V, is a series of proton pumps. The last of which, complex V, supplies protons to a proton-sensitive ATPase and thereby generates ATP. CPT1,2 indicates carnitine palmitoyltransferase 1,2; FA, fatty acid; PDH, pyruvate dehydrogenase; and TCA, tricarboxylic acid (Krebs cycle). Reproduced with permission from Huss and Kelly.30 Copyright © 2005, American Society for Clinical Investigation. [Powerpoint File]

Myocardial Viability: Survival Mechanisms and Molecular Imaging Targets in Acute and Chronic Ischemia

Myocardial Viability: Survival Mechanisms and Molecular Imaging Targets in Acute and Chronic Ischemia

Henry Gewirtz, Vasken Dilsizian

Key myocyte organelles and ion channels and their function under conditions of ischemia and reperfusion. Ischemia (left panel) causes influx of Ca2+ and decline in pH, both of which, if not severe, facilitate maintenance of closed mitochondrial permeability transition pore (mPTP). On reperfusion (right panel), key events include restoration of physiological pH, burst of reactive oxygen species (ROS) from mitochondria, release of Ca2+ from the sarcoplasmic reticulum (SR), and opening of mPTP which results in collapse of its Δψ. Reproduced with permission from Hausenloy and Yellon.27 Copyright © 2013, American Society for Clinical Investigation. [Powerpoint File]

Noninvasive Imaging in Adult Congenital Heart Disease

Noninvasive Imaging in Adult Congenital Heart Disease

Luke J. Burchill, Jennifer Huang, Justin T. Tretter, Abigail M. Khan, Andrew M. Crean, Gruschen R. Veldtman, Sanjiv Kaul, Craig S. Broberg

Three-dimensional (3D) echocardiographic quantification. In this example, left atrial and left ventricular volumes are measured using semiautomated border detection in a 3D echocardiogram. Ejection fraction can be derived without the geometric assumptions that limited 2D-derived measures, such as Simpson biplane and the area–length method. [Powerpoint File]

Noninvasive Imaging in Adult Congenital Heart Disease

Noninvasive Imaging in Adult Congenital Heart Disease

Luke J. Burchill, Jennifer Huang, Justin T. Tretter, Abigail M. Khan, Andrew M. Crean, Gruschen R. Veldtman, Sanjiv Kaul, Craig S. Broberg

Liver imaging in Fontan-associated liver disease. A, Contrast computed tomographic scan of upper abdomen in a patient with heterotaxy and a Fontan circulation demonstrating a well-circumscribed tumor measuring 5 cm in diameter in the right lobe of a midline liver (yellow asterix). B, Fluorodeoxyglucose-positron emission tomographic scan in the same patient demonstrating abnormal uptake in the right lobe of the liver in the region of the tumor. [Powerpoint File]

Neurodevelopmental Abnormalities and Congenital Heart Disease: Insights Into Altered Brain Maturation

Neurodevelopmental Abnormalities and Congenital Heart Disease: Insights Into Altered Brain Maturation

Paul D. Morton, Nobuyuki Ishibashi, Richard A. Jonas

A, Cortical gyrification increases throughout fetal and perinatal brain development. Legend demarks the 4 lobes of the cortex. B, Gyrification indices and (C) cortical surface areas of fetuses with hypoplastic left heart syndrome (HLHS) compared with normal fetuses. Adapted from Dubois and Dehaene-Lambertz (A)14 and Clouchoux et al (B and C)15 with permission of the publishers. Copyrights © 2015, 2013, Elsevier and Oxford University Press, respectively. Authorization for this adaptation has been obtained both from the owner of the copyright in the original work and from the owner of copyright in the translation or adaptation. [Powerpoint File]