Calcium and Excitation-Contraction Coupling in the Heart

Calcium and Excitation-Contraction Coupling in the Heart

David A. Eisner, Jessica L. Caldwell, Kornél Kistamás, Andrew W. Trafford

Structures involved in Ca cycling. A, Schematic diagram. This shows surface membrane, transverse tubule, sarcoplasmic reticulum (SR), and mitochondria, as well as the various channels and transporters mentioned in the text. B, High-resolution transverse section of a ventricular myocyte showing t-tubule network. Reprinted from Jayasinghe et al39 with permission of the publisher. Copyright ©2009, Biophysical Society. C, Cartoon of dyad emphasizing the major proteins involved in Ca cycling. B-AR indicates beta adrenoceptor; MCU, mitochondrial Ca uniporter; NCX, sodium–calcium exchange; NCLX, mitochondrial Na–Ca exchange; PMCA, plasma membrane Ca-ATPase; RyR, ryanodine receptor; and SERCA, sarco/endoplasmic reticulum Ca-ATPase. [Powerpoint File]

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